Product Detail

VALSART S

Generic Name: Sacubitril and Valsartan
Dosage Form: Tablets
TG Name: Cardiovascular

What is Valsart S^®?

Valsart S^® is a combination of a neprilysin inhibitor and angiotensin II receptor blocker. It is used in the treatment of Heart failure. It reduces the risk of hospitalization and death due to long lasting (chronic) heart failure.

How Valsart S^® works?

Delivers sacubitril a pro-drug; further metabolized to the neprilysin inhibitor and thus saves natriuretic peptides and valsartan an AT1 receptor blocker to reduce the blood pressure in a normalized range.

Who should not take Valsart S^®?

In patients with a history of angioedema related to previous ACEi or ARB therapy, with concomitant use of ACEi. Do not administer within 36 hours of switching from or to an ACEi, with concomitant use of aliskiren in patients with diabetes.

What are the dosage & administration of Valsart S^®?

The recommended starting dose is 49/51 mg (100mg) orally twice daily. Double the dose after 2 to 4 weeks to the target maintenance dose of 97/103 mg (200mg) twice daily, as tolerated by the patient. Reduce the starting dose to 24/26 mg (50mg) twice daily for: Patients not currently taking an angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin II receptor blocker (ARB) or previously taking a low dose of these agents.

What are the adverse effects of Valsart S^®?

Angioedema, Hypotension, Impaired Renal Function, Hyperkalemia, Cough, and Dizziness.

How Valsart S^® comes to the market?

Valsart S^® 50 mg Tablet
Valsart S^® 100 mg Tablet
Valsart S^® 200 mg Tablet

NIVIX Pharmaceuticals Limited